Devote yourselves to prayer, being watchful and thankful.
If there’s one thing we should do more than anything else, we ought to pray. One could well argue that we ought to be in the word, and meditate on it as a first priority as well, and that’s true. And the apostles spoke of prayer and the ministry of the word, referring to the praying which must accompany their public teaching and preaching.
There are no shortage of things to pray for: our own need and the needs of others. Of course worship and praise of God and confession of sin are staples in our lives in Christ. Prayer here is probably in reference primarily to petitions to God on the basis of God’s promises and the revelation of who God is along with what God wills.
We’re told that along with such prayer, we’re to be watchful and thankful. Possibly watchful for God’s answers, as well as to understand what we ought to pray for in the first place. We’re simply to have an attitude of being alert, awake, again watchful, so that we can both see what to pray for, and anticipate the answer to come.
And we need to be quick to give thanks to God for answers to prayer. As well as having a generally thankful attitude as we pray and await God’s answer. God is good and faithful to his promises. But we must continue in prayer, devoted to it. In and through Jesus.